https://nova.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 The effect of patient-managed stress dosing on electrolytes and blood pressure in acute illness in children with adrenal insufficiency https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:42671 Wed 31 Aug 2022 16:25:18 AEST ]]> Predictors of hypertensive disorders in pregnancy in women with and without polycystic ovary syndrome: The Australian Longitudinal Study of Women's Health https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:43735 Wed 28 Sep 2022 10:43:49 AEST ]]> Spontaneous and tetracosactide-induced anti-ACTH antibodies in man https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:23884 1-24) antibodies. Design: Anti-ACTH binding activity was investigated using immunoblotting and ELISA on sera from participants in the trial (n = 13; baseline and after tetracosactide exposure), 131 unrelated patients with AAD, 92 patients with Graves' disease (GD), 15 patients with isolated ACTH deficiency and 102 controls. Immunohistochemistry of human pituitary tissue sections was also performed using pooled sera. Results: Bands at approximately 4 and 6 kDa, corresponding to ACTH1-24 and full-length ACTH1-39, respectively, were found in 10 of 13 (77%) of sera from trial patients exposed to tetracosactide, including all those who had an adverse reaction. This is in contrast with healthy control sera, which showed no binding. The same 10 subjects also showed high levels of binding to tetracosactide by ELISA, along with 21% of patients with AAD, 14% of patients with GD (both P < 0·001 compared to controls) and 1 isolated ACTH deficiency patient (7% of 15). These sera also recognized native ACTH in human pituitary sections. Conclusion: Our study demonstrates that repeated administration of depot tetracosactide can lead to anti-ACTH1-24 autoreactivity. In addition, a significant number of patients with AAD and GD also had similar, spontaneous, anti-ACTH reactivity. The presence of these antibodies could mediate some of the adverse effects or explain the well-described phenomenon of resistance to chronic ACTH therapy.]]> Wed 11 Apr 2018 12:16:46 AEST ]]> Negative associations of ideal family size achievement with hypertension, obesity and maternal age in women with and without polycystic ovary syndrome https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:50858 Wed 09 Aug 2023 10:07:20 AEST ]]> High-dose preoperative cholecalciferol to prevent post-thyroidectomy hypocalcaemia: A randomized, double-blinded placebo-controlled trial https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:36646 Tue 23 Jun 2020 09:22:45 AEST ]]> Changes over time in hip fracture risk: greater improvements in men compared to women https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:49875 Thu 08 Jun 2023 13:57:36 AEST ]]> Causal relationship between body mass index and fetuin-A level in the asian population: a bidirectional mendelian randomization study https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:17504 Sat 24 Mar 2018 08:04:05 AEDT ]]> Variations in the management of acute illness in children with congenital adrenal hyperplasia: an audit of three paediatric hospitals https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:33673 Mon 02 Dec 2019 14:46:09 AEDT ]]> Menstrual cycle regularity as a predictor for heart disease and diabetes: Findings from a large population-based longitudinal cohort study https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:45760 Fri 04 Nov 2022 11:02:10 AEDT ]]>